I've only used two so far, an Edelbrock, and a Holley Street Avenger. I don't plan on using another Edelbrock.
The Edelbrock is an alright carb. The Holley is just far more tunable and user friendly in my opinion. Many people will tell a newbie that an Edelbrock is a great first carb because it's so easy to work with, but after experiencing both, I don't agree. The "hassle" with a Holley is that the fuel has to be drained for many changes and this is not necessary on an Edelbrock. But on the Edelbrock, you have linkages, more screws, small clips to loose, etc that you don't have to deal with on a Holley. This is even more of a pain when you're tuning and have to deal with a hot carb on a hot engine. I'll take draining a little fuel over all that other stuff any day.
Edit:
I thought I'd elaborate a little more. With the Edelbrock, tuning aside, there were two things I did not like. First, when cornering, the engine would starve and begin to hesitate. I heard that it is a common problem with them. I did not try to fix that. I wasn't too happy about it. I thought if I'm experiencing this with a 45 year old, stock suspension truck, it must suck in a car that can actually handle. And this was not experienced while cruising, more often when making a left hand turn to get across two lanes of highway so it's not that big a deal, but still. Second, there was significant hesitation when the secondary air valve began to open. On a Holley, you just swap springs. On an edelbrock, you have to grind on the counterweights so it's pretty well a permanent change and you risk removing too much. But certain newer Edelbrock models do have an adjustable secondary air valve. Supposedly this is not required for most Edelbrock installs.
When I got the Holley, I had it running better in a few hours than I did in several years with the Edelbrock - and that was with zero prior Holley experience - I pretty well knew every part inside an Edelbrock like the back of my hand at that time, I had it apart so many times trying to get rid of that hesitation before I learned about the air valve modification.
Lawrenceville, GA