What is the altitude where you live? This will affect things at least by a couple of jet sizes.
I have never ran this particular carb on my y, but from the others I have I would speculate that #66's are probably a bit big for the primary side. Are the jets in the primary the same as secondary? For a stock y, with that large a carb, I would be willing to bet that a 55-58 primary & 64-68 secondary would be adequate.
Alot of the others on this site have used Holleys with a great deal of luck.. I like to tinker with carbs on my schedule, so I do not use Holley.. I personally think Murphy & Holley are cousins!