The early Y truck engines used a four bolt two barrel carburetor (a teapot two barrel Holley) of which the carburetor bolt pattern looks to be very similar to the Rochester pattern. I have one of these intakes in the stack and will take a closer look if you’re interested. Just let me know.
But in answer to your original question, a single 500 cfm Rochester would be worth a try regardless if it’s on a 3X2 intake with the end carbs blocked off or on a two barrel specific intake. Just be sure that the carb bores at the carburetor flange at least match the carburetor size.