People have had success doing a seal replacement with the engine still installed.
The rear main seal is blamed for many leaks that are not from the rear main. Before going through all of that work, be sure it is the problem.
These include but are not limited to: valley pan, oil filter or adapter, oil pump, valve covers, bolt missing from the rearmost hole in the intake flange on the head, lack of thread sealer on the studs in the rear main seal retainer, side seals that were not trimmed when the rear main was installed, bent oil pan, cam plug, oil galley plugs.
Lawrenceville, GA