Expanding a little on what Frank and Ted have said it is helpful to define "back pressure" and then discuss the static and dynamic issues involved.
Back pressure is the pressure in exhaust manifold caused by the worst flow restriction which is usually the muffler. As the piston accends the cylinder and the exhaust valve is open stuff will flow out of the ex port as long as the pressure in the cylinder is higher than the back pressure in the exhaust manifold. This is the simplest view of the situation and might be called the static case. It is realistic for mild street engines with stock or nearly stock exhaust components that don't rev too high. The point here is that there is very little chance that the stock type system will ever develop negative pressure, but reducing the positive pressure will usually help power and milage.
However cars with open or closed headers tuned to length can easily develop negative pressure under the exhaust valve. This happens on purpose so that the intake and exhaust gases will develop speed and therefore inertia which will allow the cylinder to be "packed" with a denser mixture of fuel/air. The exhaust system aids this packing by removing the spent exhaust gases faster and in the process speeding the intake flow, increasing its inertia. A long overlap cam helps this at the right speed. In addition a well designed set of headers will send a reverse pulse back up the pipe just as the ex valve is closing ramming some good mixture back into the cylinder. All this is intended to take place at WOT where the goal is the worst milage possible which is also most power!
This slippage of air/fuel mix into the exhaust is not what is needed for good milage at part throttle operation. The design of the system to reduce the slippage into the exhaust is what gives higher back pressure.
Doug T
The Highlands, Louisville, Ky.
